Biosynthesis of Prostacyclin: Protein Structure and Gene Expression of Prostacyclin Synthase
نویسندگان
چکیده
منابع مشابه
Human Prostacyclin Synthase Gene and Hypertension
Background—Prostacyclin (prostaglandin I2) is a strong vasodilator that inhibits the growth of vascular smooth muscle cells and is also the most potent endogenous inhibitor of platelet aggregation. Therefore, it has been considered to play an important roles in cardiovascular disease. On the basis of the hypothesis that variations of the prostacyclin synthase gene may also play an important rol...
متن کاملSelective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer.
BACKGROUND We tested the hypothesis that combined cyclooxygenase-1 (COX-1) and prostacyclin synthase (PGIS) gene transfer selectively augments prostacyclin production without a concurrent overproduction of other prostanoids. METHODS AND RESULTS ECV304 cells were transfected with bicistronic pCOX-1/PGIS versus pCOX-1 or pPGIS, and prostanoids were analyzed. Contrary to the high prostaglandin E...
متن کاملRegional variability of prostacyclin biosynthesis.
To investigate the regional variability in arterial and venous endothelial prostacyclin (PGI2) biosynthesis, we obtained 1-cm segments of carotid arteries, external jugular veins, femoral arteries and veins, iliac arteries and veins, inferior venae cavae (IVC), and aortas from 17 dogs. Vessel luminal PGI2 production was measured in the basal state by radioimmunoassay of 6-keto-prostaglandin F1 ...
متن کاملManipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer.
Inhibition of cyclooxygenase (COX) activity decreases eicosanoid production and prevents lung cancer in animal models. Prostaglandin (PG) I(2) (PGI(2), prostacyclin) is a PGH(2) metabolite with anti-inflammatory, antiproliferative, and antimetastatic properties. The instability of PGI(2) has limited its evaluation in animal models of cancer. We hypothesized that pulmonary overexpression of pros...
متن کاملHuman prostacyclin synthase gene and hypertension : the Suita Study.
BACKGROUND Prostacyclin (prostaglandin I(2)) is a strong vasodilator that inhibits the growth of vascular smooth muscle cells and is also the most potent endogenous inhibitor of platelet aggregation. Therefore, it has been considered to play an important roles in cardiovascular disease. On the basis of the hypothesis that variations of the prostacyclin synthase gene may also play an important r...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1997
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.24.9_449